ATP Synthase

Related Products

ATPases are a class of enzymes that catalyze the decompositionof ATP into ADP and a free phosphate ion. This dephosphorylation reaction releases energy, which the enzyme (in most cases) harnesses to drive other chemical reactions that would not otherwise occur. Some such enzymes are integral membrane proteins and move solutes across the membrane, typically against their concentration gradient. These are called transmembrane ATPases. Transmembrane ATPases import many of the metabolites necessary for cell metabolism and export toxins, wastes, and solutes that can hinder cellular processes. Such as the sodium-potassium exchanger (or Na⁺/K⁺ ATPase) and the hydrogen potassium ATPase (H⁺/K⁺ ATPase or gastric proton pump) that acidifies the contents of the stomach.

ATP Synthase Related Products (43)
Antibodies (5)

By Effects:	Inhibitors (36) Activators (2) Modulator (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-158415

ATPase-IN-4	Inhibitor	≥98.0%
ATPase-IN-4 (Compound MS1) inhibits the ATPase activity of EHD4 (IC₅₀: 0.92 μM). ATPase-IN-4 also inhibits EHD2 enzymatic activity

HY-150983

ATP synthase inhibitor 2	Inhibitor	99.93%
ATP synthase inhibitor 2 is a Pseudomonas aeruginosa (PA) ATP synthase inhibitor (IC₅₀=10 μg/mL). ATP synthase inhibitor 2 can inhibit Pseudomonas aeruginosa (PA) ATP synthesis activity completely at 128 μg/mL.

HY-148973

ZW290	Inhibitor	99.60%
ZW290 is a compound to activate brown adipose tissue (BAT) thermogenic function. ZW290 increases the expression of uncoupling Protein 1 (UCP1) protein and inhibits ATP synthesis in BAT.

HY-10250S1

Triciribine phosphate-d₃	Inhibitor
Triciribine phosphate-d3 (TCN-P-d3) is a deuterated compound of Triciribine phosphate (TCN-P). TCN-P inhibits adenosine monophosphate (AMP)-activated protein kinase through an allosteric mechanism, affecting the first key step in de novo purine biosynthesis. Triciribine phosphate also inhibits inosine monophosphate dehydrogenase, which is the first key step in guanosine nucleotide synthesis. Triciribine phosphate does not affect ligase activity .

HY-113126A

3-Hydroxyisobutyric acid sodium	Inhibitor
3-Hydroxyisobutyric acid sodium is an intermediate in the metabolic pathways of L-valine and thymine, and can be found in urine. 3-Hydroxyisobutyric acid sodium is a secreted mediator of endothelial cell fatty acid transport and insulin resistance. 3-Hydroxyisobutyric acid sodium can also inhibit key enzymes of energy metabolism in the cerebral cortex of young rats. The levels of 3-Hydroxyisobutyric acid sodium are closely related to various diseases such as 3-hydroxyisobutyric aciduria, diabetes, and ketoacidosis.

HY-121908

FCPT	Inhibitor
FCPT, an ATP competitive inhibitor, induces a tight-binding of kinesin-5 onto microtubules and induced loss of microtubules selectively at the poles of Xenopus extract spindles without altering microtubule dynamics.

HY-W017540S

Cyclocreatine-¹³C₃
Cyclocreatine-¹³C₃ is the ¹³C-labeled Cyclocreatine (HY-W017540). Cyclocreatine, a creatine analogue, acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine can be phosphorylated and dephosphorylated by creatine kinases. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion in dogs and rats. Cyclocreatine decreases plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology. Cyclocreatine is proming for research of ischemic heart disease, cardiovascular diseases, Alzheimer’s disease and other neurodegenerative diseases associated with microglial dysfunction, prostate cancer.

HY-168006

NSC819701	Inhibitor
NSC819701 is a triazole inhibitor of the p97 ATPase. NSC819701 inhibits the activity of p97 ATPase by binding to a specific site of p97.

HY-113038

D-α-Hydroxyglutaric acid	Inhibitor	≥98.0%
D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling.

HY-162804

ATP synthase inhibitor 3	Inhibitor
ATP synthase inhibitor 3 (compound PT6) is an orally active inhibitor of mycobacterial F-ATP synthase (IC₅₀=0.788 μM). ATP synthase inhibitor 3 inhibits the growth of Mycobacterium tuberculosis H37Rv strain (ATCC-27294) in vitro and depletes intracellular ATP levels at an IC₅₀ value of 30μM.

HY-125637

Venturicidin B	Inhibitor
Venturicidin B (Aabomycin A2) is a macrolide antibiotic isolated from Streptomyces sp., used as an antifungal agent, a potent inhibitor of the mitochondrial F0-ATP synthase complex.

HY-149736

ATP Synthesis-IN-3	Activator
ATP Synthesis-IN-3 (compound 31) is an ATP hydrolysis inhibitor with protective effects during myocardial ischemia. ATP Synthesis-IN-3 can increase the ATP content of ischemic cardiomyocytes, increase the phosphorylation of PKA and phospholamban, and inhibit ischemia-induced apoptosis.

HY-131800

3'-Deoxy-3'-amino-ATP
3'-Deoxy-3'-amino-ATP, an ATP analogue, is a potent and competitive inhibitor of ATP, with a K_i of 2.3 μM. 3'-Deoxy-3'-amino-ATP can be used to synthesis of 3′-Amino-3′-deoxy transfer RNA by incorporation into the 3' terminus of tRNA-C-C.

HY-168005

NSC799462	Inhibitor
NSC799462 is a triazole inhibitor of p97 ATPase. NSC799462 inhibits p97 ATPase activity (IC₅₀ = 15 nM) by binding to a specific site on p97 and causing local changes in the p97 structure.

HY-150983A

ATP synthase inhibitor 2 TFA	Inhibitor	99.97%
ATP synthase inhibitor 2 (Compound 22) TFA is a Pseudomonas aeruginosa (PA) ATP synthase inhibitor (IC₅₀=10 μg/mL). ATP synthase inhibitor 2 TFA can inhibit Pseudomonas aeruginosa (PA) ATP synthesis activity completely at 128 μg/mL.

HY-157046

ATP Synthesis-IN-2	Inhibitor
ATP Synthesis-IN-2 (Compound 5) is an antibacterial compound. ATP Synthesis-IN-2 is a potent ATP synthesis activity inhibitor with IC₅₀ against Pseudomonas aeruginosa (PA) Value of 0.7 μg/mL.

HY-113126R

3-Hydroxyisobutyric acid (Standard)	Inhibitor
3-Hydroxyisobutyric acid (Standard) is the analytical standard of 3-Hydroxyisobutyric acid. This product is intended for research and analytical applications. 3-Hydroxyisobutyric acid is an important interorgan metabolite, an intermediate in the pathways of l-valine and thymine and a good gluconeogenic substrate.

HY-W779800

D-α-Hydroxyglutaric acid-¹³C₅ disodium	Inhibitor
D-α-Hydroxyglutaric acid-¹³C₅ disodium is the ¹³C-labeled D-α-Hydroxyglutaric acid (HY-113038). Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified.

HY-157045

ATP Synthesis-IN-1	Inhibitor
ATP Synthesis-IN-1 (Compound 4), quinoline derivative, is a potent inhibitor of PA ATP synthesis activity. ATP Synthesis-IN-1 has PA ATP synthesis inhibition with IC₅₀ value of 11.1μg/mL. ATP Synthesis-IN-1 also has antibacterial activity. ATP Synthesis-IN-1 can be used for the research of drug-resistant PA infection.

HY-N8265

Abyssinone V	Inhibitor
Abyssinone V is a prenylated flavonoid with predicted anti-viral activity. Abyssinone V can be isolated from the stem bark of Erythrina melanacantha. Abyssinone V possesses good pharmacodynamics properties. Abyssinone V is predicted to be antivirals including anti-herpes (HSV) agent, with mechanisms comprising inhibition of polymerase, ATPase and membrane integrity.

Name
Email *

	Sorry, but the email address you supplied was invalid.

ATP Synthase

ATP Synthase

ATP Synthase Related Products (43)

Antibodies (5)

ATP Synthase Related Products (43):